Despite Luke Cage's genetically enhanced skin, his advantages only hold up against conventional weapons. Adamantium is one of several substances he's vulnerable to. Thankfully, Cage has never had to square off against a Wolverine or an Adamantium weapon, but the danger is definitely there.
If there's any part of Luke Cage's body that is vulnerable to a simple blow is his head because a blunt trauma to his head can affect him as seen in Marvel's The Defenders story arc when Elektra is able to leave him unconscious by landing a blow to his head.
Hard exterior, chewier center: While Luke's exterior is extremely resilient, his inner body, his eyes, his mucus membranes are far less durable than his exterior. Though he may be able to withstand and recover from chemical attacks like mace in record time, he can be affected by them, if he is caught off-guard.
Lasers. Adamantium isn't the only thing that can cut Luke Cage though, he once had to have surgery on his internal organs. To be able to perform the surgery, his skin was pierced by the use of high powered lasers. Now we're talking some serious lasers, lasers that can break titanium steel.
However, Luke Cage of the Defenders acquires an impenetrable skin after experimental genetic treatment, and thus he did not naturally develop his ability. The impenetrable skin of Superman and Luke Cage is continually “active,” meaning that they are unable to “turn on or off” their power as desired.
It was only by heating up Cage's body at a high temperature that Claire Temple and Noah Burstein were able to remove all the shrapnel from Cage's body, saving his life, causing Cage's durability to increase, helping him to withstand Judas Bullets.
His strength was definitely superhuman, but it was nothing compared to the Hulk. The Hulk was far stronger than Cage even during his first appearances, and his capacity for great feats quickly ballooned.
He's super strong, like Jessica Jones and Danny Rand, but his defining physical trait is his impenetrable skin. You can't shoot Luke Cage — the bullets just bounce right off him. But Luke is certainly not unkillable.
If the star's weight was equivalent to the weight of Sol, the Hulk is capable of lifting 2 octillion tons. These numbers are far beyond human comprehension, and the laws of physics as humanity understands them simply do not apply to the Hulk; lifting a mountain is a trivial matter.
Cap can't hurt cage with regular or nerve strikes, throws even i they are off a building, he can't overpower him, he can't choke him out, and cap can't summon chi like ironfist, or buildup energy and release it like blackpanthers' suit. He can hit him with his shield until he loses it.
Luke Cage possesses superhuman strength and stamina, and has extremely dense skin and muscle tissue which render him highly resistant to physical injury. Cage possesses these abilities as a result of a cellular regeneration experiment which fortified the various tissues of his body.
Accelerated Healing Factor: Luke's invulnerability is usually enough to protect him from damages. However, if injured, Luke's recovery time from injury or trauma is customarily one-third that of an ordinary human. This ability allows for him to rarely require medical attention after even his most tedious of fights.
While Deadpool 2's Juggernaut was doubtlessly powerful, the original version is an unstoppable force of nature. In Uncanny X-Men #183, Juggernaut destroyed Colossus (and the bar they were in) yet again, and even when both combatants were magically amped in Fear Itself Colossus never got a clear victory.
Juggernaut's power is unlimited, especially when sponsored by Cyttorak. And with his willingness to win any fight, he could even manipulate Colossus, though he's never been shown to be that clever. Juggernaut would really only need to land a single hit on Colossus to knock him out and make him lose him armored form.
After grabbing the former Juggernaut, Colossus realizes he can't stop him and ends up pushing him more than 600 MPH. The Serpent has to intervene and teleports the hammer-wielding villain out of harm's way, knowing he would be defeated if he kept fighting the unstoppable Colossus.
Diamondback (Willis Stryker) is a fictional character appearing in American comic books published by Marvel Comics. He is primarily an enemy of Luke Cage and is notable for being the first major supervillain that he faced.
But when the two finally tracked down the sadistic villain, she discovered that Luke had been under Kilgrave's control the whole time. In order to save herself, and at Luke's behest, Jessica shot Luke, incapacitating him.
At Seagate Prison, Bushmaster coerced Noah Burnstein into utilizing the "Power Man" process on him to an even greater extent that was used on Luke Cage. Power Man, Iron Fist, Misty Knight, and Colleen Wing fought Bushmaster at Seagate Prison where Bushmaster proved to be more powerful than Luke Cage.
Jesse has almost identical powers which was how he managed to put up a fight against Luke. On the other hand, Luke has unbreakable skin and strength comparable to, if not stronger than Jessica's. As a straight brawler, Jessica was always good in a fight.
