While Thanos ranks far from the top 10 villains in the Marvel Universe, The Mad Titan is powerful enough to effortlessly put down Deadpool. Given the latter ever fights Thanos with Infinity Gauntlet and all the Infinity Stones, The Mad Titan can easily erase Wade from existence, ending the fight in an instant.
Characters like Blink, Domino, and Colossus have unique abilities that can give them an advantage over Deadpool. Characters with strong telepathic powers, such as Jason Stryker and Professor X, could potentially overpower Deadpool's chaotic mind.
On that occasion, Wolverine proved he was stronger than Deadpool, who still went as Weapon XI at the time. The tilt between the former Team X members ended with Wolverine decapitating his foe, seemingly ending their rivalry. However, Wade Wilson survived the fatal blow thanks to his extraordinary regeneration powers.
He is somewhat the same in the comics, so if Deadpool ever faced Thor, the god of thunder would have the winning edge. It's true that Deadpool managed to terminate Thor using Pym Particles in a non-canon comic by enlarging Mjolnir. But MCU Thor never needed Mjolnir in the first place.
Deadpool is easily one of the most powerful characters Marvel has. The fast-talking gunman seems almost fearless on the battlefield, but in reality, there's a lot that scares the Merc with the Mouth. There are two things though, that scare him above all: cows and clowns are a Deadpool weakness.
Weapons like the Cosmic Cube, Infinity Gauntlet and the Enigma Force could enable practically anyone to defeat Thanos. Deadpool used these tools well, but he certainly couldn't have killed the powerful villain without them. On his own, the mercenary wouldn't stand a chance against the Mad Titan.
In a fight, Loki would win 10/10. Who will win a fight between Lobo and Deadpool? Lobo, hands down. Sure, they're both insane and have crazy levels of being able to regenerate, but the Main Man has a couple of distinct advantages over the Merc with the Mouth.
Wolverine and Deadpool have fought many times, each getting some wins. However, Deadpool probably has a lead in wins and losses between the two. Wolverine definitely can beat Deadpool and is stronger than him, but Deadpool's speed and healing factor have allowed him to get the drop on Wolverine and do a lot of damage.
On that occasion, Wolverine proved he was stronger than Deadpool, who still went as Weapon XI at the time. The tilt between the former Team X members ended with Wolverine decapitating his foe, seemingly ending their rivalry. However, Wade Wilson survived the fatal blow thanks to his extraordinary regeneration powers.
5) Hulk. Marvel fans can imagine how a fight between Deadpool and The Hulk will take its course. With the green superhero smashing his way through Wade's brain matter, the fight will be over as soon as it starts.
As intelligent as Bruce Wayne is, there's little he'd be able to do to defeat Deadpool. He may have plenty of gadgets that could hurt or maim Wilson, and he's also fairly skilled in the art of combat, but the Dark Knight's own moral code would be his downfall.
"Spider-Man would beat Deadpool. Easily. Because Deadpool loves Spider-Man, and therefore could never bring himself truly to hurt Spider-Man. Spider-Man would take Deadpool down, but still visit him both in the hospital and later in prison.
The simple answer is no. Yes, Hulk absolutely smashes Thor to the ground with Mjolnir, but, he's holding both Thor and the hammer. Hulk wouldn't have been able to lift Mjolnir by himself, but since the God of Thunder had a firm grip on it as well, he was able to use it as a weapon against his teammate.
However, one of Deadpool's most brutal kills occurred against Thor when he used Ant-Man's Pym Particles to transform Mjolnir into an even deadlier weapon, which the God of Thunder's great powers can't even stop.
There's been confusion among fans about whether or not Loki is worthy of wielding Thor's hammer, but Marvel has finally confirmed that the God of Mischief can indeed lift Mjolnir. The Immortal Thor #4 complicated the issue of Loki's worthiness by not allowing him to solely be the one to lift Mjolnir.
Marvel has revealed just how powerful Deadpool's healing factor really is – and it turns out that it's powerful enough to allow Wade Wilson to survive a nuclear bomb blast at close range! Deadpool had to put his healing factor to the ultimate test in Uncanny Avengers #5.
As powerful as Cosmic Ghost Rider is, Immortal Hulk would destroy him. Castle couldn't do anything that would actually kill him, which would give Immortal Hulk time to destroy his opponent. While Immortal Hulk is certainly the most powerful Hulk, even other forms could defeat Cosmic Ghost Rider.
Deadpool kills Wolverine by using a sword made from carbonadium that slows down his healing factor, stabbing him and nullifying his regeneration. X-23 temporarily defeats Wolverine's healing factor by hacking and slashing at him and adding dirt to his wounds, preventing his skin from repairing itself.
In Deadpool Annual 2013, Deadpool is ripped apart by Luke Cage and Thor. He's split straight down the middle, but he had been melded together with Madcap for the duration of the issue, so the two halves simply become each of them.
In the comics, Weasel often regards himself as Deadpool's best friend, although due to Deadpool's mental instability and erratic behavior, it leads to him abusing or mistreating Weasel. In the comics, Weasel is Deadpool's friend, sidekick, information broker, and arms dealer.
Again, the implications of this are still a mystery, even to Deadpool. This caused Thanos, who was in love with Mistress Death, to curse Deadpool with immortality.
