In the early years of Punisher's career as a vigilante, his main foe is the Costa crime family, those responsible for the deaths of his innocent wife and children. In particular he targets Billy Russo AKA Jigsaw, who remains one of Frank's longtime foes.
Billy Russo deciding to call himself "Jigsaw". Billy Russo, better known as Jigsaw, is a vicious criminal mastermind from the Marvel universe. He mainly appears as the archenemy to the violent vigilante Frank Castle, and is the main antagonist of the Punisher franchise.
Lieutenant William "Billy" Russo, also known as Jigsaw, is the main antagonist of the Netflix series Marvel's The Punisher. He once was the best friend and squad mate of Frank Castle during their time in the U.S. Special Forces. He also leads Anvil, a private military contractor in New York City.
Billy Russo was one of Castle's closest friends from his military days, but Russo's betrayal – providing Rawlins with the information that led to the massacre in the park – turns them into vicious enemies.
Upon leaving the Marine Corps, Russo was recruited by Rawlins to contribute to his illegal operations, gaining a financial reward and the ability to create his own company with Anvil. Russo's desire for power led him to betray Castle, allowing Rawlins to assassinate Castle's family.
Colonel Ray Schoonover and Operation Cerberus leader William Rawlins organized the hit on Frank Castle's wife and children to deter the budding antihero from exposing their deeds, though their plot would quickly backfire as Castle sought revenge.
Weaknesses. Non-Superhuman Physical Conditioning: Castle is as susceptible to physical injury and disease as any other normal human, often having to rely more on strategy than strength when up against a superhuman opponent.
As both crews clash, Matt and Frank make a beeline for each other. They argue religious semantics, with Frank hating the Christian version of god for taking his family away.
Kingpin - A ruthless crime lord and the archenemy of Daredevil, indeed uncontested as Daredevil's greatest enemy. The Kingpin also serves as an enemy for the Punisher and Spider-Man. Kirigi - A ninja assassin after being resurrected by the Hand.
A mercenary for hire, he played an important role in the series Deadpool; T-Ray served to remind Wade Wilson, also known as Deadpool, what a failure he was. He is Deadpool's archenemy for many issues and almost everything that happened to Deadpool was a part of an elaborate plan orchestrated by him.
I know that Daredevil and Spidey often clash with Punisher, as has Nick Fury. Furthermore, Punisher is shown to have respect for the other heroes, particularly Captain America but it seems that nobody really respects Punisher.
One of the most feared, dangerous and powerful crime lords in the Marvel Universe, usually depicted as New York City's crime overlord, the Kingpin was introduced as an adversary of Spider-Man, but later went on to be the archenemy of Daredevil, as well as a recurring foe of the Punisher, and his adoptive daughter Echo.
The Leader (Samuel Sterns) is a supervillain appearing in American comic books published by Marvel Comics. The Leader first appeared in Tales to Astonish #62 (December 1964), created by writer Stan Lee and artist Steve Ditko as the archenemy of the Hulk.
Frank Castle's Punisher didn't really have super-villains. Sure, there were a few recurring eccentric bad guys like Jigsaw and Barracuda, but any super-villain the Punisher fought belonged to other superheroes, including the likes of Kingpin, Hammerhead, and Tombstone (all of whom are Spider-Man/Daredevil rogues).
Punisher would lose in hand to hand combat so he could without even fighting Cap with multiple rounds of shots since Cap can still get mortally wounded but even that would require some luck because it's never really easy to kill Rogers as one way or another, he always come back.
There's a possibility the Punisher could get the better of Batman in a chance first encounter, but Batman's superior skills, training, and resources would quickly tip the scales in his favor.
What is the meaning of One Batch, Two Batch to the Punisher? Heads up - it's a bit of a sad explanation. In the MCU, One Batch, Two Batch is a rhyming children's story that became a favorite of Lisa Castle, daughter of Frank.
Maria Elizabeth Castle (née Falconio) is the wife of Frank Castle in Marvel Comics. The character, created by Gerry Conway and Tony DeZuniga, first appeared in Marvel Preview #2 (Aug. 1975).
See: the scene in which he pays his mother a visit. His mother is bedridden, but not by natural causes; Billy keeps her sedated (or paralyzed) using drugs. It's his way of getting payback for her discarding him, thereby forcing him to grow up in group homes, which weren't the best environment for him.
Frank Jr. then made an inappropriate comment about the jihadists being killed by his father and the United States Marine Corps. Frank Sr. lost his temper and threatened his son, something he instantly regretted as he apologized to Frank Jr.
Fearing for his own life, Gunner fled to the wildness of Kentucky, where he lived off the grid until Castle tried to contact him, thus leading the CIA to Henderson's hideout. Gunner and Castle fought off their attackers, but Gunner received a wound and died of blood loss.
