Deadpool's healing factor is unique, having merged with his cancer so that Wade regenerates damaged body parts with dead tissue and therefore needs this power to live. However, when taken to the next level, Wade's healing factor didn't just heal damage - it built him back better.
Deadpool possesses a superhuman healing factor derived from that of the mutant Wolverine that allows him to regenerate damaged or destroyed bodily tissue with far greater speed and efficiency than an ordinary human.
Establishing the first connection between Deadpool and Wolverine, the latter's DNA was placed inside Wilson, allowing his regenerative healing factor to emerge. While Deadpool operated without scars for a short time, his healing factor began to react to his cancer, causing scarring akin to his live-action adaptations.
The way his healing factor works is that as long as a single cell of Deadpool remains, any and every part of his body is capable of regenerating at an alarming rate. This allows Deadpool to survive everything from a stab through the heart to decapitation.
Most likely, Deadpool would have to place his head back onto his neck, and it will then Regenerate in that location. This is also seen possible because of this, yes I know this is just epic cover art to build suspense, but it shows us that Deadpool can actively hold his head rather than it just regenerating instantly.
His power is so effective that it allows him to be immortal despite him carrying his cancer. But that doesn't mean he is unkillable. One way of killing him is to put a mutation-dampening collar on his neck. It will disable his regenerative ability and allow the cancer cells to grow, thus deteriorating his body.
Since there was no technical injury, the two guys come out unscathed and fully formed. In Deadpool's Dark Reign storyline, his head had to be sewn back onto his body after it was severed to begin the healing process.
Marvel has revealed just how powerful Deadpool's healing factor really is – and it turns out that it's powerful enough to allow Wade Wilson to survive a nuclear bomb blast at close range! Deadpool had to put his healing factor to the ultimate test in Uncanny Avengers #5.
Along with his extra mutant powers, one of the things Stryker did to Wilson was have his mouth surgically shut, making him the perfect soldier in Stryker's eyes. In the post-credits scene his mouth is partially open.
In multiple comics over the years, it's been established that Deadpool's healing factor is more powerful than Wolverine's. Deadpool can survive anything. If his head is cut off, he'll regrow his body over a few weeks. He can heal almost instantly from pretty much any wound.
While Wade does get inebriated if he drinks a lot of alcohol, his body's super-powerful immune system protects him from getting drunk easily, meaning that Wilson needs a lot of alcohol in his system before he can even remotely be affected.
Revealed at one point that Deadpool saved Spider-Man's life after he died on the field of battle by giving him a transfusion of his mutated blood, this secretly executed Lazarus effect successfully keeps Peter breathing, but in the long run, results in some unintended consequences that see him live an unnaturally long ...
That was until he was approached by the shady Department K which offered to cure his cancer if Wade would join the 'Weapon X' program. Wade accepted and was granted a superhuman healing factor, but his face and body became permanently disfigured (both physically and mentally) as a result.
Yes, Deadpool feels every bit of pain as normal humans do. However, his regenerative ability allows him to heal from all injuries. While Deadpool can heal quickly, he isn't indestructible.
Deadpool's healing factor rapidly creates dead cells to replace other cells that are perpetually dying, as opposed to healthy ones like Wolverine, as his healing factor was artificially linked to his terminal cancer during his Weapon X experimentation.
Deadpool's strength lies in his incredible healing factor and combat skills, as well as his unpredictable and fourth-wall breaking nature. Wolverine possesses an impressive healing factor, adamantium skeleton, and keen senses, but is vulnerable to certain attacks and has weaknesses like the Muramasa Blade.
Rogue needed to heal, and Deadpool decided to give her his healing factor through skin contact, by kissing her. Deadpool's powers, abilities and even his inner voices were absorbed by Rogue, who recovered while Deadpool fell unconscious.
While the Hulk was easily able to survive the barrage of nuclear weapons, the noise of the explosions and cries of dying people eventually came to bother him. The Hulk returned to his birthplace in New Mexico and sealed himself in a cave with a massive boulder, trapping Banner inside with him for many years.
Eventually, Wade gets out from under Stryfe's thumb, but the real miracle is that Deadpool survives the freezer in the first place, whether he is left insane or not.
However, to Deadpool's dismay, he's not healing and continues to bleed out as the issue ends. Alcaudón goes on to explain that Deadpool is being affected by "the most fascinating poison. One graze and it stops the blood from clotting. It shuts down the body's ability to heal.
