The timeline only mentioned that the Enterprise-E left service around 2408, but its ultimate fate was unclear; however, by 2409, a new Odyssey-class (β) vessel was christened Enterprise (β) (NCC-1701-F), implying that her predecessor was decommissioned or destroyed.
Sisko later heard that Worf's Klingon problems and his thirst for vengeance against the Klingon Empire did indeed lead to the destruction of the - thankfully empty - freighter. It's possible, therefore, that Worf's Klingon bloodlust also played a part in the situation that led to the destruction of the Enterprise-E.
However, when revealing that he rebuilt Enterprise-D, Geordi says, “And obviously, we can't use the Enterprise-E.” This statement seems to imply that Enterprise-E was destroyed. Additionally, it seems it was so badly destroyed that it was beyond fixing, leaving Geordi to work on Enterprise-D instead.
By the time of Star Trek: Picard, Worf has become a subcontractor for Starfleet Intelligence, having attained the rank of Captain and briefly commanded the Enterprise-E beforehand.
UPN canceled Star Trek: Enterprise due to low ratings and a lack of network support for the series. Enterprise season 4 involved a creative shift with Manny Coto taking over as showrunner, but it couldn't save the series from cancelation.
Star Trek: Picard showrunner Terry Matalas recently revealed that Worf (Michael Dorn) captained the USS Enterprise-E after Jean-Luc Picard (Patrick Stewart).
The novel Preserver by William Shatner, Judith Reeves-Stevens and Garfield Reeves-Stevens suggested that the USS Enterprise-E was capable of separating.
The Enterprise-E was never destroyed onscreen, but Star Trek: Picard season 3 revealed Captain Worf (Michael Dorn) took command after Jean-Luc Picard's promotion to Admiral. The Enterprise-E was subsequently lost in a mysterious event that Worf claims was not his fault.
What is the difference between Enterprise-E and D?
The Enterprise-D is a peacetime cruise ship, which is fine for week-to-week adventures where you're attending trombone recitals or getting de-aged or quietly contemplating the nature of sentience. The Enterprise-E is for cinematic world-saving, built by a Starfleet that was being squeezed by the Dominion and the Borg.
The Enterprise-H was originally the USS Endurance (NX-90000). After the loss of the USS Enterprise-G, the Endurance was renamed Enterprise. The Enterprise-H was launched in 2420 as a replacement for the Constitution III-class USS Enterprise-G, which had been taken by Separatist forces some months earlier.
In Star Trek: Nemesis, the Enterprise is heavily damaged while stopping Shinzon from using a weapon of mass destruction to destroy all life on Earth. The ship returns to spacedock to undergo extensive repairs.
It didn't exist during the Dominion war. The Dominion war began in 2373. The Enterprise-D was destroyed in 2371, two year prior to the war. This is in Star Trek: Generations.
The Enterprise-F was an Odyssey-class starship and was the seventh Federation starship to bear the name Enterprise. The vessel was under the command of Admiral Elizabeth Shelby during the events of Frontier Day in 2401.
Admiral Janeway cameo considered for Picard Season 3, but showrunner Terry Matalas feared it would overshadow Seven of Nine's story. Seven of Nine's journey in Picard Season 3 was one of the best story arcs, starting as First Officer and ending as Captain of the Enterprise-G.
Warning: SPOILERS for Star Trek: Picard Season 3, Episode 9 - "Vox"Star Trek: Picard season 3 showrunner Terry Matalas confirms that Worf (Michael Dorn) became Captain of the USS Enterprise-E after Jean-Luc Picard (Patrick Stewart) was promoted to Admiral.
For many of those years, there was more than one Trek show airing, not to mention movies regularly hitting the silver screen. This overload of content created franchise fatigue; John Billingsley even cited this fatigue as a reason when asked why Enterprise failed.
Enterprise killing off Trip in its finale was meant to give the character's story closure, but it completely backfired, as did "These Are The Voyages..." overall.
While the death of Duras was in keeping with Klingon law and tradition, Picard considered it unacceptable for a Starfleet officer to kill another in this manner, and entered a formal reprimand in Worf's record. Worf left Starfleet in late 2367 to fight in the Klingon civil war on behalf of Gowron.
Picard season 3 was set two decades later and turned the fate of the Enterprise-E into a gag, with Goerdi noting the ship wasn't available and Worf defensively saying it wasn't his fault, leaving it a mystery.
Star Trek: The Magazine claimed that the banquet area seen aboard the USS Enterprise-E during the beginning of Star Trek: Insurrection is that ship's Ten Forward (October 2001, volume 2, issue #6). Although the room was on Deck 10, there was no dialogue or signage which explicitly identified it as Ten Forward.
