Yes, Homelander can fly, but his powers, including heat vision, super strength, and durability, wouldn't be a problem for Thanos. Given his physiology as an Eternal, Thanos, even without the Infinity Stones, could outmatch Homelander, as he's stronger and can take way more damage as he's practically invulnerable.
If there is one person who can single handedly defeat Thanos, who would it be? There are several characters in Comics who can achieve this mammoth feat but we will only focus on the ones who were part of MCU: ODIN: Needless to say, the most powerful being introduced in MCU. The Skyfather Odin himself.
With enough training, Quicksilver would have been more than capable of defeating Thanos when he finally arrived in Infinity War. Unfortunately for the Avengers, Quicksilver heroically sacrificed his life in order to save Hawkeye and a civilian boy during the Battle of Sokovia.
Matthew Waterson noted to Phase Zero that Thanos' Infinity Gauntlet is metal, suggesting that Magneto could have easily stripped Thanos of his most powerful weapons, rendering him all but powerless, and making him easier to take down.
Many believe that Homelander is unstoppable, but he is nowhere near as strong as Goku. Homelander can level a major city without much difficulty, but Goku can destroy the entire planet with a single Ki blast. Homelander's body may be tough, but it's not that tough.
Homelander wouldn't know what to do if he ever came across somebody as strong as himself, much less somebody far more powerful. Hulk could quickly flick the antagonist of The Boys across the Atlantic Ocean.
Thanos and Hulk have clashed several times in Marvel lore, with Thanos even admitting he was scared to face the Hulk before acquiring the Infinity Stones. While Thanos is usually the victor, it's generally down to him using superior tactics and technology, rather than simply possessing greater physical strength.
Although he is an extremely skilled marksman, Clint Barton is often considered to be the weakest member of the team seeing as he's just a regular guy with a bow and arrow.
Although Homelander is one of the main antagonists of the comic series, he is not killed by his archenemy Billy, but is instead killed by Black Noir. His name literally means "A person from one's homeland". It is suggested that the homeland he's born from would be America (due to his outfit).
Homelander may appear strong, but he would be no match for characters like Superman or Wonder Woman in a face-to-face battle. Green Lantern's ring and Zatanna's magical abilities could easily trap or defeat Homelander, showing that physical strength isn't always necessary.
Seeing as he would have lost against Thanos without the upgrade of his new weapons, it's clear who the victor would be in a confrontation between the Mad Titan and Adam. A battle between the god-tier Thanos and Black Adam would be insane, but in the end, Thanos would walk away victorious.
This Gen V revelation not only proves that Homelander has a clear weakness but also highlights how Supersonic was literally a walking weapon against several supes in The Boys and could even kill Homelander with his Sonic Clap powers.
Even breaking the rules of this comparison and factoring in a world where Homelander can attain access to a supply of the rare mineral Kryptonite, Superman's superior tactical knowledge and combat training would still likely best Homelander in a Homelander vs Superman fight.
In terms of speed, power, and durability, Superman and Goku (in SSJ2) are pretty much even. However, Goku's martial arts training gives him an edge against Superman. Superman might have gotten some training as well, but it has not been covered or written about as extensively as Goku's.
But, all the Superman-like abilities he possesses are weaker than the ones that Man of Steel himself has. Homelander's flight speed, super strength, and durability in particular are inferior to Superman's. On top of that, he doesn't possess freeze breath either.
Homelander is too fast (faster than sound), too loud and the calorific sight allows him to fight from a distance while also using flight. Spider-Man can get as angry as he wants, but in a fight he couldn't beat the best "supereoe" of the boys.
Homelander is Indestructible. Batman and the Batsuit aren't. And Homelander has no weakness like Kryptonite that we know off. So as Batman , if the Bat meets the Homelander head on - its Curtains for Batman.
As Skyfather of Olympus, Zeus wields power comparable to Odin, whose wrath Thanos has withstood but not bested. At the same time, Zeus cannot truly die. While the most powerful of Olympians can be badly wounded or even dismembered, he can never actually pass on into oblivion.
As it stands, Batman alone is helpless against cosmic level threats, much less against Thanos. Really, the best thing he could do is to ask for the Hellbat armor from the Justice League so he can survive Thanos' physical attacks. Even then, he'll still lose.
