Right after Anakin dons the Darth Vader mask and takes his first mechanical breath, Padmé takes her last breath and passes away. Darth Vader awakens, and his first question is about the whereabouts of Padmé. Palpatine tells Darth Vader that in his anger he killed her, placing the blame for Padmé's death on Vader.
He did find out. Once he learnt of Luke's existence, Vader of course understood that Padme didn't die as a result of his Force choke. For the first time in decades, Vader had a motive to overthrow his Master.
He still believed Palpatine was telling the truth when he said he would help save Padme. So, from Vader's distorted point of view, Palpatine had done nothing wrong and was the only person left by his side. And rather than lose everyone in his life, he figured he might as well commit to his life as a Sith.
Why did Palpatine tell Anakin that he killed Padmé?
Ultimately, Palpatine's genius evil plan revolves around corrupting the young Jedi Anakin Skywalker and turning him to the Dark Side. Padmé's death would serve to push Anakin further toward the Dark Side as his rage and anger built to a crescendo.
Return of the Jedi, however, proved that Palpatine had a significant blind spot. There were plenty of warning signs Palpatine could have heeded that Vader might turn on him, and yet his ignorance and arrogance led to his decisive downfall.
George Lucas Explains Padme's Death (NOT Palpatine)
Why didn't Vader betray Palpatine earlier?
In Star Wars: Return of the Jedi, Darth Vader felt defeated and more importantly trapped, again. He was still reeling over Luke's rejection of his offer and felt that at this juncture, he was far too gone to the dark side, so he might as well remained loyal to Emperor Palpatine.
And he's already murdered Mace Windu at Palpatine's behest, more or less by stabbing the Jedi in the back. The canonical comic Star Wars: Darth Vader #7 confirms the younglings' deaths caused Anakin grief, self-loathing, hatred, and pain, fueling his descent even further into the Dark Side.
When Anakin had to choose between losing Padme — fearing that she might die in childbirth — or turning to evil to “save” her from death, he chose evil. His desire to “save” her at all costs led Anakin to the dark side. For him, the dark side became a means of saving his loved one.
Anakin does not have even the slightest bit of remorse. By the end, he feels nothing but anger. Although he feels regret for killing Padme, he still helps the evil Emperor. The film ends with Anakins standing side by side with the man on whose behalf he has committed all his crimes.
Thus, he never had any romantic relationships again after Padme's death. Even if he wanted to, I highly doubt he could have after all the injuries he sustained on Mustafar, anyway. If this were real life, he would have died on Mustafar after Obi-Wan chopped off his limbs and left him to burn alive.
Anakin's Force Choke begins the series of injuries that ultimately leads to Padme's death, and convinces Obi-Wan to fight him. Despite this, when Anakin learns of Padme's death, his immediate reaction of grief and regret shatters everything in the lab with a powerful force shockwave.
Sadly the Clone Wars would have still happened, but Padmé would have also survived, giving birth to Luke and Leia who would have probably been inducted into the Jedi Order. As for what would have happened between the two, with their marriage and all, that's a bit tricky.
So overall, it seems highly likely that the answer is no, Palpatine didn't have the power to save Padmé's life. He hadn't even begun learning the power when Anakin became Darth Vader, and the idea of saving lives was of no interest to him.
In the illustrated screenplay of Star Wars: Episode III Revenge of the Sith, Amidala was scripted to be holding the japor snippet after Anakin awakens from his first nightmare, during her time in her private apartment on Coruscant after Obi-Wan's warning about Anakin's fall to the dark side, and during her final ...
Anakin's vision did come true, as Padmé, heartbroken by her husband's downfall, loses her will to live and succumbs while giving birth to twins. Before her death, Padmé still believed there was still good left in Anakin and that one day he could be saved with the help of their children.
Anakin Hated Obi-Wan Because of an Imagined Relationship With Padme. Although Padme and Obi-Wan's affair couldn't have been further from the truth, Anakin apparently built up a scenario in his mind, which was only heightened by the Jedi Council's obfuscation in other areas.
“The tear [on Anakin's face] says that he knows what he's done, but he has now committed himself to a path that he may not agree with… but he is going to go on anyway. It's the one moment that says he's self-aware that he's rationalizing all his behavior.
Obi-Wan spared Anakin despite knowing killing him would "burn his heart to ash" and feeling regret for what Anakin could have become. Obi-Wan's decision to spare Anakin was influenced by the dark feeling that accompanied Emperor Palpatine's arrival, preventing him from finishing him off.
He cared for Vader only as a tool and weapon. Palpatine was a great actor. He played the part he needed to whenever he needed to. To further his goals and his quest to put a split between Anakin and the J…
He often refers to Vader as a tool that can be discarded when he is no longer of any use, and yet still Vader obeys. Despite wanting Vader to obey, Palpatine still sees his apprentice as pathetic and someone who could never surpass him.
