In the main Star Wars timeline, of course, Darth Vader's attempts to resurrect Padmé on Mustafar were doomed to failure. But it's fascinating to speculate what would have happened had he been successful. In that scenario, Padmé Amidala's return from the dead would not have provided the solace Darth Vader sought.
It's clear that Darth Vader wishes that Padmé joined him so that they could have remained together. But there are moments in Marvel's other Darth Vader series that suggest that, while the Sith Lord is very much still obsessed with the idea of Padmé, her betrayal may have caused him to think ill of his late wife.
Though Anakin's affection for Padmé was always sullied by darkness, in the end, it led to one of the truest forms of love that Anakin had ever known and Star Wars has ever seen — that between a father and a son.
Darth Vader awakens, and his first question is about the whereabouts of Padmé. Palpatine tells Darth Vader that in his anger he killed her, placing the blame for Padmé's death on Vader. Vader denies it, saying he sensed Padmé was still alive, which the audience knows she was as Obi-Wan escaped on the ship with her.
VADER OPENS THE PORTAL TO BRING PADME BACK BUT…(CANON) - Star Wars Theory Comics
Did Anakin regret killing Padme?
Anakin does not have even the slightest bit of remorse. By the end, he feels nothing but anger. Although he feels regret for killing Padme, he still helps the evil Emperor. The film ends with Anakins standing side by side with the man on whose behalf he has committed all his crimes.
Before he could enter, however, Vader was stopped by Sabé, Eirtaé, Rabé, Saché, and Dormé, former handmaidens of Amidala, who refused to let him enter into the grave so he would not desecrate it. However, Vader would not be denied. As he entered the tomb, he became flooded with memories of Amidala.
Anakin truly did care for Padme, except Anakin was not at all in his right mind when he choked her. Anakin has many issues, he has tramua both from war and childhood, he has sever fear of loss and he is extremely loyal to the ones he chooses to befriend. This all comes into play in this moment when he chokes her.
Before Padmé's death, she still believed there was still good left in Anakin, and that one day he could be redeemed. During Anakin's time as the Emperor's enforcer, he continued to suffer from grief over Padmé's death, and guilt over his supposed hand in it.
Darth Vader: Who Is the Greater Dark Lord? The short answer is yes, without a doubt, Vader regretted becoming a cybernetic monstrosity. First, there's the constant pain and discomfort from his suit. Worse, however, is the psychological pain.
So overall, it seems highly likely that the answer is no, Palpatine didn't have the power to save Padmé's life. He hadn't even begun learning the power when Anakin became Darth Vader, and the idea of saving lives was of no interest to him.
The story is Anakin was manipulated to the dark side by Palpatine based on fears of losing Padme and appeals to his desire power and agency, over his life and the galaxy as a whole.
What he did not see, at the time at least, was that Padmé used her last breaths to tell Obi-Wan that she was certain that in regards to her husband, "there's still good in him." Now, those words are set to be revealed to someone other than Darth Vader himself.
Thus, he never had any romantic relationships again after Padme's death. Even if he wanted to, I highly doubt he could have after all the injuries he sustained on Mustafar, anyway. If this were real life, he would have died on Mustafar after Obi-Wan chopped off his limbs and left him to burn alive.
He had no idea Padmé had given birth before she died, still less that the Jedi had spirited the children away and hidden them. Darth Vader's illusions were shattered shortly after the destruction of the first Death Star.
However, Kenobi did not understand the significance of her gesture, only understanding Amidala's basic feelings about it, and returned it to her. After her death, Amidala's body held the japor snippet during her funeral procession, and was buried alongside her body in a privately owned mausoleum.
Obi-Wan only believed Anakin could be saved when Luke did on Endor. So, at that moment on Mustafar, Obi-Wan should have finished Anakin, but he didn't have the courage to do it because ironically he had an attachment to Anakin.
While Force healing could have saved Padmé, material from both continuities explains why Anakin couldn't use it. The Force is a fundamental omnipresent energy that can be used as “powers” by those who are trained to tap into it. One such power is healing oneself or another at an enhanced speed.
He was trying to deform Padmé's personal ship. And it works. The entire hull is burnt to a crisp. Soon Vader's castle is constructed in such a way that will channel enough dark energy to open a gateway to another world so he can resurrect Padmé.
Despite this, when Anakin learns of Padme's death, his immediate reaction of grief and regret shatters everything in the lab with a powerful force shockwave.
To hide the birth of her twins from both Darth Vader and more importantly Palpatine. The fact that Amidala had given birth to twins was a secret known only to a few after her death. The mortician Commodex Tahn used a hologram to make her still appear pregnant during her funeral.
This fell in line with various fan theories and non-canon novelizations that suggested Obi-Wan and Padmé had an affair sometime during the Clone Wars. In the Star Wars prequel movies, Obi-Wan often has a duty to protect Padmé, but there was never any sense of romantic feelings.
This time jump makes Padmé a very mature 24 years old, while Anakin is still a Jedi Padawan and teenager at the age of 19. This formidable time in their lives is when the romance between the two sparks, so the age difference between Padmé and Anakin doesn't hold them back.
