While Luke Cage hasn't died in the main universe, other versions of him have been killed in multiverses. The most notable example is when Deadpool snuck miniaturized bombs into his coffee to get around his impenetrable skin.
Luke Cage's main weaknesses are that 1) his internal organs aren't any more durable than a normal human's and 2) that he needs to breathe like the rest of us. If you can manage to penetrate his skin and muscle tissue, you can severely injure or kill Luke Cage.
Upon his returning, Diamondback tracked down Luke Cage on the Harlem streets where he walked with Claire Temple. Armed his special rifle with Judas Bullet, he took aim and fired a single shot, hitting Cage in the stomach and penetrating his seemingly unbreakable skin.
More powerful than the investigator, despite her own super-strength, Luke nearly killed Jessica, who reluctantly shot him at point blank range in the head with a shot gun to stop him. The blow didn't kill Cage, but did cause some serious cranial swelling, knocking him unconscious.
But when the two finally tracked down the sadistic villain, she discovered that Luke had been under Kilgrave's control the whole time. In order to save herself, and at Luke's behest, Jessica shot Luke, incapacitating him.
The pink slipping of Luke Cage was ultimately a combo of the age old Hollywood “creative differences” and the inability for the parties involved to reach a deal on how to move forward, according to sources.
This also made Luke Cage's early bouts against Cottonmouth, Diamondback and Stiletto seem almost paltry, but this scope matched his initial power set. His strength was definitely superhuman, but it was nothing compared to the Hulk.
Reva was the doctor from the prison, then became Luke's wife. So Jessica murdered her and then I read that she actually tells him she was the one that did it to prevent him from killing the bus driver.
Luke Cage possesses superhuman strength and stamina, and has extremely dense skin and muscle tissue which render him highly resistant to physical injury. Cage possesses these abilities as a result of a cellular regeneration experiment which fortified the various tissues of his body.
Jesse has almost identical powers which was how he managed to put up a fight against Luke. On the other hand, Luke has unbreakable skin and strength comparable to, if not stronger than Jessica's.
Diamondback (Willis Stryker) is a fictional character appearing in American comic books published by Marvel Comics. He is primarily an enemy of Luke Cage and is notable for being the first major supervillain that he faced.
His current level of durability enables him to withstand gun fire at point-blank range, and can withstand being lit on fire without suffering any serious or permanent injuries.
Also known as Power Man, Cage was created by Archie Goodwin, John Romita, Sr. and George Tuska. Here's the cover of the first issue, Luke Cage, Hero for Hire #1. Cage was imprisoned for a crime he did not commit, but gains superpowers in the form of unbreakable skin and superhuman strength.
Now in full command of his powers, Luke's superhuman strength allowed him to lift thousands of pounds and punch through four-inch thick steel. His skin also proved to be impervious to bullets, thanks to the incredibly dense muscle tissues created by the experiment.
Due to her constant presence as a force for good across New York, Jones became close with fellow NYC Super Hero Luke Cage. After a stuttering start to their relationship—with no shortage of awkward encounters—the two started a romance that would eventually mature into a marriage.
While they investigate, Cage forgives Jones for her role in Connors' death, and the two begin to grow close again. They find a nightclub where Kilgrave tested his enhanced powers, and are confronted by him there.
Born and raised by Super Heroes Luke Cage and Jessica Jones, Danielle Cage inherits her parents' phenomenal powers. While still a babe, the mad Titan Thanos arrives in her time, invading Project P.E.G.A.S.U.S. to build a pair of cosmic cube iso-gauntlets.
The two brawlers have fought beyond these two encounters, but these two fights establish a few hard facts: the Hulk can be overpowered by the Juggernaut; the Hulk cannot consistently stop the Juggernaut; and most importantly, the Hulk's strength, even at maximum, cannot harm the Juggernaut at his maximum power.
It's Cage's indestructible skin that's going to give Wolverine a hard time. Wolverine has dealt with enemies much stronger than his former teammate before, but the fact he can't damage Luke means he'll need help to take him down.
Luke Cage (born Carl Lucas), and also called Power Man is a fictional character and superhero from Marvel comics, appearing as the main protagonist of the titular comics, and a major character in the Avengers and Defenders comics.
