Iron Man Made the Ultimate Sacrifice to Defeat Thanos During Endgame, The Avengers traveled through time to acquire the six Infinity Stones and snap back everyone originally blipped in Infinity War using Tony Stark's Nano Gauntlet.
Thanos' death in Avengers: Endgame by Iron Man wielding the Infinity Stones is the most iconic and satisfying death in the MCU. Thanos' beheading by Thor in Avengers: Endgame is a darkly satisfying moment of character development and raises intrigue for the plot.
After escaping to the Garden and destroying the Stones, he is eventually killed by Thor. Five years later, an alternate version of Thanos from 2014 time travels to 2023 to battle the Avengers once again, but is killed by Tony Stark.
If by fully powered you mean that he has all the stones, then yes, depending on circumstances. Thor gained the upper hand on him with all the stones, and Wanda and Dr. Strange both took on a Thanos, who had almost all of them. Captain Marvel also stands a chance here.
Thanos is trapped in a pocket limbo of stasis by his son. Thanos is freed by Namor and was among the villains that joined his Cabal to destroy other worlds. Thanos later meets his end on Battleworld, where he is easily killed by God Emperor Doom during an attempted insurrection.
Tony Stark tricks Thanos by taking not the new Infinity Gauntlet, but the Infinity Stones themselves, which slide into slots on his armor. He snaps his fingers and erases Thanos and his army — but Tony dies in the process.
Mjølnir: Thor was wielding the magical Uru hammer, which he had lost when he was banished from Asgard. However, before Thor could retrieve the Mjølnir from S.H.I.E.L.D., he was killed by Hawkeye.
The attempt ultimately was unsuccessful, however, as Thanos had destroyed the Stones to avoid temptation, rendering the goal impossible. Thor settled for the hollow victory of killing the Mad Titan out of revenge for the deaths of the victims, effectively ending the Infinity War.
Eric fought well, but even the real Thor would have fallen beneath Thanos' infinite might. Only Thanos could defeat Thanos, thanks in part to his own self-loathing.
Yes Loki is dead, he got killed by Thanos in Avengers Infinity War (2018). But the Loki from the Loki series, is indeed Loki, but not the same Loki that died in Infinity War.
In the 2019 film Avengers: Endgame, Iron Man (Robert Downey, Jr.) steals the infinity stones from Thanos and transfers them to his own suit. When Iron Man snaps, he gets rid of Thanos's army, but this action kills him.
After a long search, Ronan acquired the Orb, but after realizing it had housed the Power Stone, he instead betrayed Thanos and chose to take the Orb's power for himself. Using his new-found power, he and his forces attacked Xandar, only to be defeated and killed by the Guardians of the Galaxy.
Thanos has just taken the 6th stone, he's poised to decimate half the Universe. Suddenly, a wild Thor appears, and throws his axe at Thanos, striking him in the head and splitting it in two. And Thanos dies.
Thanos only hijacked Thor's ship, murdered his brother with his bare hands, stabbed his best friend through the aorta, slaughtered half of what remained of his people, left him floating in the middle of space like a discharge from the sewage tank, and then proceeded to obliterate half the universe on what Thor ...
Thanos snaps half of all living things away before Thor can kill him, but in Endgame, Thor went for the head and killed Thanos. This proved that the God of Thunder could defeat the Mad Titan with or without the big gold glove.
The trick worked for a while till Thor outsmarted Loki in Thor: Ragnarok. So far, that was the only film in the trilogy where Loki didn't "die." His final, final death came at the hands of Thanos in Avengers: Infinity War.
When Thanos got control over all six Infinity Stones, he became one of the most powerful beings in the Marvel Universe, though on his quest to obtain them, Thanos revealed that he was afraid to face the Hulk.
Thanos and Hulk have clashed several times in Marvel lore, with Thanos even admitting he was scared to face the Hulk before acquiring the Infinity Stones. While Thanos is usually the victor, it's generally down to him using superior tactics and technology, rather than simply possessing greater physical strength.
But the one being Thanos hates more than anyone is the Merc With A Mouth himself, Deadpool – a rivalry that MCU fans are likely going to miss. While many fans may not expect this rivalry, Thanos and Deadpool have been at odds for quite some time.
This is shown later in the series, where heroes acting on a precognitive vision of a rampaging Hulk, Bruce was then shot in the hypothalamus by Hawkeye who was hiding on a tree nearby.
By far the most brutal death is when Deadpool kills Spider-Man while wearing the Venom symbiote. Deadpool uses the symbiote's ability to bypass Peter's spider-sense in order to ambush him. He then quickly overpowers Spider-Man, and horrifyingly, eats his brain while Peter is completely helpless to stop him.
