Only a few select people can withstand his seemingly endless talking, and his mouth is sewn shut in the final act of X-Men Origins: Wolverine. Ajax also threatens to sew Wade's mouth shut in Deadpool when he is undergoing his cancer treatment because of his nonstop talking.
This question is answered by the fact that Deadpool's cancer hasn't actually been cured but simply put on pause, meaning it is constantly battling with his healing factor, causing his severe disfigurement, which will assumedly still be in place when Deadpool joins the MCU in Phase 5.
Since his artificially-gifted healing factor is tied to those cancerous cells, healing them actually eliminated Deadpool's 'healing factor'. Therefore, Deadpool doesn't have a 'healing factor' at all, but a 'dying factor', as the cells that regenerate are cancerous, not healthy.
However, they are not identical. Deadpool has the superior healing factor, significantly. Professor X once stated that Wolverine could, most likely, be killed if he was decapitated. Deadpool can still move his body around normally even with a decapitated head.
According to Deadpool's mouth was never sealed. Also deadpool doesn't have adamantium rods as shown in origins movie. He is The Merc with the Mouth, so he will speak.
There it is established that the reason for Deadpool not regenerating is purely psychological, his low self-esteem is what stops him from returning to his normal appearance.
Yes, Deadpool feels every bit of pain as normal humans do. However, his regenerative ability allows him to heal from all injuries. While Deadpool can heal quickly, he isn't indestructible.
Most likely, Deadpool would have to place his head back onto his neck, and it will then Regenerate in that location. This is also seen possible because of this, yes I know this is just epic cover art to build suspense, but it shows us that Deadpool can actively hold his head rather than it just regenerating instantly.
Deadpool might have his fair share of comedic moments in the Marvel universe, but the mercenary's powers allow him to be one of the strongest Marvel characters, proficient enough to defeat and kill major Marvel heroes ranging from Captain America to The Fantastic Four.
As you all know, Wolverine kills Deadpool at the end of X-Men Origins:Wolverine, but somehow Deadpool returns around 30 or so years in the movie timeline later for 2 more solo movies and another one upcoming.
Deadpool is effectively immortal, although he has died several times. He is still alive 800 years in the future when the new X-Force encounters him. In addition, Thanos once declared that Deadpool should "consider yourself cursed ... with life!"
Deadpool is easily one of the most powerful characters Marvel has. The fast-talking gunman seems almost fearless on the battlefield, but in reality, there's a lot that scares the Merc with the Mouth. There are two things though, that scare him above all: cows and clowns are a Deadpool weakness.
When the Awareness trapped them in individual illusions, Lady Deadpool's scars somehow disappeared permanently, which she chose to conceal from her scarred Corps teammates.
In Deadpool Annual 2013, Deadpool is ripped apart by Luke Cage and Thor. He's split straight down the middle, but he had been melded together with Madcap for the duration of the issue, so the two halves simply become each of them. Since there was no technical injury, the two guys come out unscathed and fully formed.
His power is so effective that it allows him to be immortal despite him carrying his cancer. But that doesn't mean he is unkillable. One way of killing him is to put a mutation-dampening collar on his neck. It will disable his regenerative ability and allow the cancer cells to grow, thus deteriorating his body.
In multiple comics over the years, it's been established that Deadpool's healing factor is more powerful than Wolverine's. Deadpool can survive anything. If his head is cut off, he'll regrow his body over a few weeks.
Fanon. Most shipping was originally based on Wade being a major fan of Peter's superhero identity, Spider-Man. His hero worship of the other causes him to want to be a better person. Shippers were also drawn to their similar senses of humor, since they both have tendency to sass and quip.
Thanks to Deadpool's healing factor he can regenerate from almost any injury, including being literally torn in half or decapitated. His extreme resilience to damage has led many people to speculate that he may in fact be completely immortal.
Readers witnessed Wade Wilson's rapid regeneration abilities and Rogue's absorption powers work together at an unbelievable level, saving Rogue's life – and proving Deadpool can survive a nuclear blast.
Soon, Cable was revealed to be Nathan Summers, the son of Cyclops and Madelyne Pryor who was taken to a distant future as part of the ongoing war against Apocalypse.
There's not really much one can do when facing an opponent whose prime ability is to never perish. Hence, Thanos would have no chance against Deadpool if he was facing him without the Infinity Gauntlet. Thanos can eradicate entire civilizations and wipe out half of all life in the universe with a snap of his fingers.
Deadpool's new powers as Apocalypse's Famine manifest through the antihero's mouth, from which Deadpool can conjure a deadly cloud of locusts. In order to control this ability, Deadpool has his mouth sewn shut, and only breaks the stitching when he needs to unleash his disgusting yet incredibly effective new ability.
