It has been revealed that at the time his healing ability was given to him, Deadpool suffered from some form of cancer; after the healing factor was given to him, it made his normal cells as well as his cancerous cells unable to die, giving him a heavily scarred appearance beneath his suit.
Establishing the first connection between Deadpool and Wolverine, the latter's DNA was placed inside Wilson, allowing his regenerative healing factor to emerge. While Deadpool operated without scars for a short time, his healing factor began to react to his cancer, causing scarring akin to his live-action adaptations.
These "super-cancer" cells persistently destroy his healthy cells while his healing abilities rapidly regenerate them. This endless conflict between the healing factor and the cancer cells results in Wilson's disfigured appearance. His inability to heal his skin lies in his failure to cure his cancer.
Only a few select people can withstand his seemingly endless talking, and his mouth is sewn shut in the final act of X-Men Origins: Wolverine. Ajax also threatens to sew Wade's mouth shut in Deadpool when he is undergoing his cancer treatment because of his nonstop talking.
Most likely, Deadpool would have to place his head back onto his neck, and it will then Regenerate in that location. This is also seen possible because of this, yes I know this is just epic cover art to build suspense, but it shows us that Deadpool can actively hold his head rather than it just regenerating instantly.
Deadpool Encounters Juggernaut "I'm Gonna Rip You In Half Now" Scene | Deadpool 2 (2018) Movie Clip
What is Deadpool's weakness?
Deadpool is easily one of the most powerful characters Marvel has. The fast-talking gunman seems almost fearless on the battlefield, but in reality, there's a lot that scares the Merc with the Mouth. There are two things though, that scare him above all: cows and clowns are a Deadpool weakness.
Thanks to Deadpool's healing factor he can regenerate from almost any injury, including being literally torn in half or decapitated. His extreme resilience to damage has led many people to speculate that he may in fact be completely immortal.
Deadpool's new powers as Apocalypse's Famine manifest through the antihero's mouth, from which Deadpool can conjure a deadly cloud of locusts. In order to control this ability, Deadpool has his mouth sewn shut, and only breaks the stitching when he needs to unleash his disgusting yet incredibly effective new ability.
There's a reason for that. The Merc with the Mouth has an advanced healing factor derived from Wolverine's powers, but that's where those similarities end. When William Stryker pooled a bunch of mutants' powers into Wade Wilson in X-Men Origins: Wolverine, he went ahead and gave Deadpool an adamantium skeleton.
But unlike the films, Deadpool does eventually receive his old face back in the Marvel Comics... and it's absolutely stunning. In the first Deadpool film - shortly after Deadpool escapes the Weapon X program and Ajax's grasp, he meets with his buddy Weasel and reveals his scarred face.
So, Deadpool's main superpower is his healing factor, and what a healing factor it is. In multiple comics over the years, it's been established that Deadpool's healing factor is more powerful than Wolverine's. Deadpool can survive anything. If his head is cut off, he'll regrow his body over a few weeks.
Yes, Deadpool feels every bit of pain as normal humans do. However, his regenerative ability allows him to heal from all injuries. While Deadpool can heal quickly, he isn't indestructible.
That's why Deadpool can exist as a severed head, or how his dismembered limbs can actually grow a whole new Deadpool. Wade Wilson is constantly dying of cancer every moment of his life, and based on how his unnatural healing factor manifested in his body, that means nothing else can kill him.
Deadpool is a mutant who has an accelerated healing factor. He can re-grow his parts or attach them if cut from his body. He is said to have cancer, which resulted in a deformed face, but he does not die due to his heavy healing factor.
Deadpool is effectively immortal, although he has died several times. He is still alive 800 years in the future when the new X-Force encounters him. In addition, Thanos once declared that Deadpool should "consider yourself cursed ... with life!" out of jealousy over Deadpool's status as Death's love interest.
He is somewhat the same in the comics, so if Deadpool ever faced Thor, the god of thunder would have the winning edge. It's true that Deadpool managed to terminate Thor using Pym Particles in a non-canon comic by enlarging Mjolnir. But MCU Thor never needed Mjolnir in the first place.
There's been confusion among fans about whether or not Loki is worthy of wielding Thor's hammer, but Marvel has finally confirmed that the God of Mischief can indeed lift Mjolnir. The Immortal Thor #4 complicated the issue of Loki's worthiness by not allowing him to solely be the one to lift Mjolnir.
The simple answer is no. Yes, Hulk absolutely smashes Thor to the ground with Mjolnir, but, he's holding both Thor and the hammer. Hulk wouldn't have been able to lift Mjolnir by himself, but since the God of Thunder had a firm grip on it as well, he was able to use it as a weapon against his teammate.
Eventually, Wade gets out from under Stryfe's thumb, but the real miracle is that Deadpool survives the freezer in the first place, whether he is left insane or not.
Readers witnessed Wade Wilson's rapid regeneration abilities and Rogue's absorption powers work together at an unbelievable level, saving Rogue's life – and proving Deadpool can survive a nuclear blast.
