Little is detailed about Deadpool's life before the zombie plague arrived on Earth-2149, however it can be presumed that it followed much the same path as his Earth-616 counterpart. At some point he was infected, and attacked the Silver Surfer.
It has been revealed that at the time his healing ability was given to him, Deadpool suffered from some form of cancer; after the healing factor was given to him, it made his normal cells as well as his cancerous cells unable to die, giving him a heavily scarred appearance beneath his suit.
Also, Deadpool's healing factor grants him other benefits like immunity to diseases and infections, foreign chemical resistance (he can be drugged and poisoned, but it will take massive doses), extended longevity, immunity to psychics, and superhuman attributes (speed, agility, stamina, reflexes).
A little-known fact about Deadpool is that he doesn't do so well with Gamma Radiation. Deadpool's healing factor is among the most powerful in Marvel, but if the Merc with The Mouth is exposed to excessive Gamma Radiation, his healing factor is all but gone.
So, crushing his brain into a million pieces should practically kill him because, unlike Wolverine, he cannot regenerate from a single cell or a single drop of blood. For more superhero updates, check out if Gareth Edwards will direct Thor 5. Also, learn if Vanessa returns in Deadpool 3.
Deadpool & Wolverine - All Scenes in Order [UPDATED]
Why does Deadpool's face not heal?
This question is answered by the fact that Deadpool's cancer hasn't actually been cured but simply put on pause, meaning it is constantly battling with his healing factor, causing his severe disfigurement, which will assumedly still be in place when Deadpool joins the MCU in Phase 5.
In multiple comics over the years, it's been established that Deadpool's healing factor is more powerful than Wolverine's. Deadpool can survive anything. If his head is cut off, he'll regrow his body over a few weeks. He can heal almost instantly from pretty much any wound.
Most likely, Deadpool would have to place his head back onto his neck, and it will then Regenerate in that location. This is also seen possible because of this, yes I know this is just epic cover art to build suspense, but it shows us that Deadpool can actively hold his head rather than it just regenerating instantly.
Deadpool, the fourth-wall-breaking comic book hero turned movie star known as the “merc with a mouth,” is effectively immortal. No matter which way he gets sliced and diced, he does not die.
Readers witnessed Wade Wilson's rapid regeneration abilities and Rogue's absorption powers work together at an unbelievable level, saving Rogue's life – and proving Deadpool can survive a nuclear blast.
His power is so effective that it allows him to be immortal despite him carrying his cancer. But that doesn't mean he is unkillable. One way of killing him is to put a mutation-dampening collar on his neck. It will disable his regenerative ability and allow the cancer cells to grow, thus deteriorating his body.
In Deadpool Annual 2013, Deadpool is ripped apart by Luke Cage and Thor. He's split straight down the middle, but he had been melded together with Madcap for the duration of the issue, so the two halves simply become each of them. Since there was no technical injury, the two guys come out unscathed and fully formed.
As Deadpool explains, his healing factor isn't as effective at healing brain injuries as it is with injuries to his limbs and other organs. As a result, he often suffers from selective amnesia, completely forgetting about the events that led up to his head injury and the moment of the injury itself.
Deadpool has bovinophobia, which is the fear of cows. According to him, cows "scare the *#$% outta" him, as he believes their stare to be chilling, like they're "waiting."
While most people have a hard time resisting the cuteness of kittens, Deadpool notoriously mentioned that the young furry felines are his one true weakness.
Eventually, Wade gets out from under Stryfe's thumb, but the real miracle is that Deadpool survives the freezer in the first place, whether he is left insane or not.
Since his artificially-gifted healing factor is tied to those cancerous cells, healing them actually eliminated Deadpool's 'healing factor'. Therefore, Deadpool doesn't have a 'healing factor' at all, but a 'dying factor', as the cells that regenerate are cancerous, not healthy.
There's not really much one can do when facing an opponent whose prime ability is to never perish. Hence, Thanos would have no chance against Deadpool if he was facing him without the Infinity Gauntlet. Thanos can eradicate entire civilizations and wipe out half of all life in the universe with a snap of his fingers.
As an expert in the art of killing, it seems even Thanos wouldn't be powerful enough to stand against him. But even with his famous ability to snap the Marvel Universe in half, Thanos still couldn't keep Deadpool from killing him... twice.
Comics Deadpool would regenerate. He's essentially “banished from Death”, so he couldn't die even if he and the rest of the universe all wanted it and put 110% maximum effort into making it happen. Even when he's not in that state, he always seems to regenerate, no matter how implausible the circumstances.
Deadpool might have his fair share of comedic moments in the Marvel universe, but the mercenary's powers allow him to be one of the strongest Marvel characters, proficient enough to defeat and kill major Marvel heroes ranging from Captain America to The Fantastic Four.
As intelligent as Bruce Wayne is, there's little he'd be able to do to defeat Deadpool. He may have plenty of gadgets that could hurt or maim Wilson, and he's also fairly skilled in the art of combat, but the Dark Knight's own moral code would be his downfall.
On multiple occasions, the Jade Giant has proven his healing factor is one of the best in the Marvel Universe, as he's been able to survive and quickly recover from some incredible dangerous attacks. But, unlike Deadpool, he can get better in an instant.
