No one can defeat The One Above All, he is the supreme being in Marvel and a supreme being cannot be defeated, only stalemated. Plus The One Above All is the comic book incarnation of Jack Kirby and also represents the writers so he is quite literally beyond fiction.
The One Above All was one of the many victims of Thanos in his eternal quest to please Death. He was obliterated along his fellow Celestials by Thanos when he stabbed Black Bolt to death in order to use his destructive voice as weapon.
The SIMPLEST ANSWER IS HE CAN'T BE BEATEN. Literally NO matter what character you say, it just can't be done. Someone answered that The Beyonder could destroy The One Above All (or beat him) because his name means to Beyond all. The Beyonder.
In terms of powers, The One Above All's are limitless, so much so that they are beyond the scope of understanding. If Saitama were to punch him, the blow would not even phase him. In fact, the only way to even weaken One Above All is to cause some form of multiversal imbalance.
The One Above All stomps so bad there's no amount of training Goku could do to win. The One Above All is omnipotent. TOAA could just write Goku out of existence, not like Hakai, which takes time and can be resisted in the DBS manga.
15 Strongest Cosmic Gods We'll See In The Multiverse Saga
Who can defeat Goku 100?
Many fans consider Jiren to be stronger than Goku based on the exceptional abilities and feats that he demonstrated in the Tournament of Power arc. He possesses an overwhelming amount of power and strength. His raw physical abilities, immeasurable ki, and mastery of various martial arts techniques.
That said, it really does seem like Zeno will stay the strongest god in Dragon Ball for the foreseeable future. His level of power is so incomprehensible that it seems highly unlikely Goku will ever fight Zeno, let alone beat him.
However, as the scene with the mosquito suggests among the numerous opponents who have been hit by Saitama, the one person who seems most able to withstand the irresistible force of his one-punch technique is Saitama himself. From a perspective based purely on physics, Saitama should be able to survive his punch.
God claims that he can't be destroyed, but Saitama destroys him and the universe with a single overwhelming punch. Fans are left to wonder where One-Punch Man is going to go now that literally nothing exists anymore.
Scarlet Witch. Thor wasn't around during the events of Avengers Disassembled and House of M, so he missed out on Wanda losing control, and therefore he didn't have to face her full power. ...
In fact, Beerus, the God of Destruction, could probably take on the entire cast of Dragon Ball and Dragon Ball Z, even after their respective power-ups throughout Dragon Ball Super. On multiple occasions, Goku attempts to defeat Beerus, and in each instance, the God of Destruction emerges as the undisputed victor.
As powerful as Cosmic Ghost Rider is, Immortal Hulk would destroy him. Castle couldn't do anything that would actually kill him, which would give Immortal Hulk time to destroy his foe.
The One-Above-All is omnipotent (and presents himself as all-powerful) omnipresent, and omniscient, and is above all cosmic powers and abstract entities. Marvel's Zeus is just as powerful as any other incarnation of Zeus but the TOAA is the creator of everything including Zeus so this is not even a fight.
In the aftermath of his failure, Thor had a new-found determination to kill Thanos and undo the Snap. The remaining Avengers converged on the Titan's home to find him wounded and the Infinity Stones destroyed. Seeking vengeance, Thor raised Stormbreaker and, with one fell swoop, beheaded Thanos.
With this artifact Thanos was able to absorb every cosmic being that exists in his universe, eventually facing Eternity and Infinity. Despite their best effort Thanos defeats them and absorbs the two beings. He then merges with his future self finally taking the battle to the Living Tribunal and the One Above All.
Even if Goku was able to use his highest form of power, Saitama's one-punch certainty means a fight wouldn't last for long. If we are to take Saitama's power and accuracy at face value, it almost doesn't matter who his opponent is — he would win outright.
The fight would ultimately come down to who can last the longest, and Saitama is physically unmatched in every regard. A single punch would floor Goku, but the Zenkai Boost may not be enough to help.
The battle between Saitama and Thanos was intense and destructive, but ultimately, Saitama's immense strength and speed proved to be too much for even the all-powerful Thanos with all six Infinity Stones.
In a battle against Hulk, every little bit counts. Saitama having this ability provides him a slight edge, as he effectively has a source of projectile attacks that he can use at a distance.
Although Naruto's physical strength isn't on the level of Goku's, he can certainly do well against him in a fight. With Naruto's limitless chakra and other such overpowered abilities at his disposal, like the Six Paths Sage Mode, Naruto would be able to hold his own, at least for a while.
Chi-Chi quickly fell in love with Goku, who was completely oblivious to her feelings. When Chi-Chi and Goku talked about getting married and having a family, something the Ox-King was happy to set up, Goku agreed, but it was only because he thought marriage was something to eat.
While Thanos may be a more capable commander or general combatant, Goku is the perfect duelist and excels in one-on-one fights, arguably his best type of fight. That experience is much more relevant in a battle between the two, meaning that Goku comes out on top.
