Spider-Man Thinks Doc Ock is His Greatest Enemy More often than not, audiences tend to assume that the Green Goblin is Spider-Man's greatest enemy. There's precedent to that belief, as many of Peter Parker's most tragic moments have been a direct result of Norman Osborn's shenanigans.
The Green Goblin's scientific, engineering, and business savvy was evident from the start, but the way he uses his intellect to destroy the Web-Slinger's world is what makes him unique. As the man who killed Gwen Stacy, Norman Osborn is known for his ability to strike at Spider-Man's emotional core.
Through his psychotic personal torture and conflict with one of Marvel's finest as well as nearly succeeding in total world domination and the actual destruction of Asgard, Norman Osborn is truly the most evil villain in all of Marvel.
By far the most brutal death is when Deadpool kills Spider-Man while wearing the Venom symbiote. Deadpool uses the symbiote's ability to bypass Peter's spider-sense in order to ambush him. He then quickly overpowers Spider-Man, and horrifyingly, eats his brain while Peter is completely helpless to stop him.
Colossus is one of the most powerful members of his family, but he's never been able to beat Spider-Man. The two haven't clashed very often; the first time was during the first Secret Wars when Spider-Man defeated Colossus and the X-Men entirely on his own.
He compensates with enough heart to be heroic throughout the Powerless series, but as someone who's more man than spider, it should come as no surprise why he's the weakest "Spider-Man."
This is the big one. Ethyl chloride is essentially Spider-Man's Kryptonite and it renders anyone's spider-powers null and void. This makes ethyl chloride extremely powerful against Spider-Man, but this chemical cocktail doesn't have nearly the same reputation as Superman's Kryptonite.
Scientific aptitude and knowledge. Apart from his physical abilities, Peter is an intellectually-gifted scientific teen genius and has a prodigious aptitude in the physical sciences, with a high IQ level of around 250.
Deathstroke, aka Slade Wilson, is one of Batman's most fearsome enemies. His combat prowess as well as tactical understanding, are unmatched. Deathstroke is a highly trained assassin and killer who, thanks to experimental military techniques, possesses unparalleled power, speed, as well as reflexes.
Ben was killed when a burglar was robbing their house. Ben accidentally surprised him causing the burglar to shoot him. His death sparked the transformation of Peter Parker into Spider-Man. He once returned for five minutes as part of a birthday present from Doctor Strange for Peter Parker.
He is Batman's archenemy, as well as the most famous and recurring Batman villain. Waylon Jones has a medical condition that warped his body into a massive crocodile-like form. As Killer Croc descended into madness, he sharpened his teeth to razor points and began murdering innocent victims.
However Spider-Man tricks Mysterio into revealing he robbed the museum, then Spider-Man revealed he had captured it on tape. Mysterio was then jailed, blaming Spider-Man for his ruined career. Mysterio later joins the Sinister Six in an attempt at revenge on Spider-Man.
He knows how the Norse god fights, and he knows that it would be impossible for him to beat Thor. He's smart enough to know the only hope he'd have against Thor is with a group, one that would distract the god long enough for Spider-Man to make a difference in the fight.
Spider-Man's speed and agility give him an advantage over the Hulk, who is not known for being agile. Spider-Man's unknown limits of strength make him a potentially formidable opponent for the Hulk.
Mjølnir: Thor was wielding the magical Uru hammer, which he had lost when he was banished from Asgard. However, before Thor could retrieve the Mjølnir from S.H.I.E.L.D., he was killed by Hawkeye.
As you all know, Wolverine kills Deadpool at the end of X-Men Origins:Wolverine, but somehow Deadpool returns around 30 or so years in the movie timeline later for 2 more solo movies and another one upcoming.
This is shown later in the series, where heroes acting on a precognitive vision of a rampaging Hulk, Bruce was then shot in the hypothalamus by Hawkeye who was hiding on a tree nearby.
