This question is answered by the fact that Deadpool's cancer hasn't actually been cured but simply put on pause, meaning it is constantly battling with his healing factor, causing his severe disfigurement, which will assumedly still be in place when Deadpool joins the MCU in Phase 5.
These "super-cancer" cells persistently destroy his healthy cells while his healing abilities rapidly regenerate them. This endless conflict between the healing factor and the cancer cells results in Wilson's disfigured appearance. His inability to heal his skin lies in his failure to cure his cancer.
It has been revealed that at the time his healing ability was given to him, Deadpool suffered from some form of cancer; after the healing factor was given to him, it made his normal cells as well as his cancerous cells unable to die, giving him a heavily scarred appearance beneath his suit.
Since Deadpool is quite literally in a constant state of death, his healing factor is always working at a rapid pace beyond what should be possible. That's why Deadpool can exist as a severed head, or how his dismembered limbs can actually grow a whole new Deadpool.
Deadpool is a mutant who has an accelerated healing factor. He can re-grow his parts or attach them if cut from his body. He is said to have cancer, which resulted in a deformed face, but he does not die due to his heavy healing factor.
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What if Deadpool's head was cut off?
Most likely, Deadpool would have to place his head back onto his neck, and it will then Regenerate in that location. This is also seen possible because of this, yes I know this is just epic cover art to build suspense, but it shows us that Deadpool can actively hold his head rather than it just regenerating instantly.
In multiple comics over the years, it's been established that Deadpool's healing factor is more powerful than Wolverine's. Deadpool can survive anything. If his head is cut off, he'll regrow his body over a few weeks. He can heal almost instantly from pretty much any wound.
Deadpool is easily one of the most powerful characters Marvel has. The fast-talking gunman seems almost fearless on the battlefield, but in reality, there's a lot that scares the Merc with the Mouth. There are two things though, that scare him above all: cows and clowns are a Deadpool weakness.
Extended Lifespan - It is unknown how long Deadpool will live but it has been shown to be further than 800 years into the future, it is believed he is unable to die as he has established a romantic like relationship with the personification of Death.
Deadpool's new powers as Apocalypse's Famine manifest through the antihero's mouth, from which Deadpool can conjure a deadly cloud of locusts. In order to control this ability, Deadpool has his mouth sewn shut, and only breaks the stitching when he needs to unleash his disgusting yet incredibly effective new ability.
Taking a test sample of the serum actually healed every scar on Deadpool's body, gifting him back his old, attractive face. However, as is the case when afflicted heroes try and be healed in Marvel Comics, his scars eventually returned.
So, crushing his brain into a million pieces should practically kill him because, unlike Wolverine, he cannot regenerate from a single cell or a single drop of blood. For more superhero updates, check out if Gareth Edwards will direct Thor 5. Also, learn if Vanessa returns in Deadpool 3.
His power is so effective that it allows him to be immortal despite him carrying his cancer. But that doesn't mean he is unkillable. One way of killing him is to put a mutation-dampening collar on his neck. It will disable his regenerative ability and allow the cancer cells to grow, thus deteriorating his body.
There's a reason for that. The Merc with the Mouth has an advanced healing factor derived from Wolverine's powers, but that's where those similarities end. When William Stryker pooled a bunch of mutants' powers into Wade Wilson in X-Men Origins: Wolverine, he went ahead and gave Deadpool an adamantium skeleton.
When the experiment conducted on Wade gave him superhuman healing, he became unkillable but was not immune to old age. However, that changed after some time due to the most unimaginable thing possible. So, Deadpool is immortal because he has a curse from Thanos, granting him eternal life.
Between lost limbs and even decapitation, Wade Wilson has managed to sprout back up. And in most cases, it seems that his head is the key to regeneration success, seeing as it often has to be attached back onto his body to actually heal decapitation.
There's not really much one can do when facing an opponent whose prime ability is to never perish. Hence, Thanos would have no chance against Deadpool if he was facing him without the Infinity Gauntlet. Thanos can eradicate entire civilizations and wipe out half of all life in the universe with a snap of his fingers.
In the end, Deadpool wasn't worthy. While he seemingly had control of Mjolnir and the strength of Thor, it was all a mirage put on by Loki to distract Thor.
Funny enough, Domino isn't the only one with a fear of a particular animal, as Deadpool tells her he's scared of cows while gaining the information from her.
There aren't many superheroes that could defeat Deadpool without breaking a sweat, but Shazam harnesses the power of the gods to use for the greater good, so there's not much Wilson could do to stop him. He has a healing factor of his own, along with super strength, invulnerability, super speed, and the ability to fly.
The Marvel Comics character Deadpool believes that clowns are the greatest threat to the human race other than the planet eating Galactus. In the TV series Living Single, John Henton's character, Overton, displays a distinct fear of clowns.
Readers witnessed Wade Wilson's rapid regeneration abilities and Rogue's absorption powers work together at an unbelievable level, saving Rogue's life – and proving Deadpool can survive a nuclear blast.
On multiple occasions, the Jade Giant has proven his healing factor is one of the best in the Marvel Universe, as he's been able to survive and quickly recover from some incredible dangerous attacks. But, unlike Deadpool, he can get better in an instant.
